Life tree skull moon tattoos symbolize the cyclical nature of life and death, representing the interconnectedness of mortality, rebirth, and the passage of time. The tree of life, often depicted with roots and branches, signifies growth, wisdom, and the connection between heaven and earth, while the skull serves as a reminder of the inevitability of death and the transience of life. The moon, often incorporated into the design, adds an element of mysticism and guides the wearer through life's ebbs and flows.